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OCR: ns Third, it is well established that neoplas growth frequently produce hormones, cytokine hough factors and other bioactive substances, a h clinical these neoplasms are rarely associated w age of the humoral syndromes. Increasing knowle ances biological implications of bioactive subs t these produced by neoplastic cells indicates th ells or substances can act directly on neoplastic , which in tissues that surround the neoplastic cell rowth. turn function to support neoplastic cell imoral In this context, the concepts of ectopic h active syndromes and ectopic production of bic ing substances by neoplasms are now attract cientific remarkable attention from clinical and ocrinology, researchers in oncology as well as in en See also: · Ectopic Cytokine Syndromes